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Author Topic: Neuroprotection by 9 -Tetrahydrocannabinol, the Main Active Compound in Marijuana, against Ouabain-Induced In Vivo Excitotoxicity
wepeeps
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Post Neuroprotection by 9 -Tetrahydrocannabinol, the Main Active Compound in Marijuana, against Ouabain-Induced In Vivo Excitotoxicity
on: January 16, 2015, 09:23
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Excitotoxicity is a paradigm used to explain the biochemical
events in both acute neuronal damage and in slowly progressive, neurodegenerative diseases. Here, we show in a longitudinal magnetic resonance imaging study that 9-tetrahydrocannabinol (9-THC), the main active compound in marijuana, reduces neuronal injury in neonatal rats injected intracerebrally with the Na /K -ATPase inhibitor ouabain to elicit excitotoxicity. In the acute phase 9
-THC reduced the volume of cytotoxicedema by 22%. After 7 d, 36% less neuronal damage was observed in treated rats compared with control animals. Coadministration of the CB1 cannabinoid receptor antagonist SR141716 prevented the neuroprotective actions of 9 -THC,
indicating that 9
-THC afforded protection to neurons via the
CB1 receptor. In 9
-THC-treated rats the volume of astrogliotic tissue was 36% smaller. The CB1 receptor antagonist did not block this effect. These results provide evidence that the cannabinoid system can serve to protect the brain against neurodegeneration.

http://www.jneurosci.org/content/21/17/6475.full.pdf+html

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